BCN-O-Acetic Acid NHS Ester
This product is a PEG-based linker containing a bicyclo[6.1.0]nonyne (BCN) group, an acetic acid linker, and an NHS ester. It enables copper-free click chemistry with azides and efficient amine conjugation specifically for dual-functional bioconjugation.
Key Features and Benefits
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BCN Group: Performs strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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Acetic Acid Linker: Provides spacing and stability for dual reactivity.
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Dual Reactivity: Combines SPAAC click chemistry with amine coupling.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine-containing partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with orthogonal handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual-reactive groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates copper-free click reactivity with amine-reactive NHS chemistry, specifically providing a versatile scaffold for bioconjugation and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
