Tetrazine-Ph-SS-amine, Tetrazine-SS-amine is a cleavable linker designed for targeted drug delivery and bioconjugation. It features a tetrazine group for fast, bioorthogonal reactions with strained alkenes like trans-cyclooctene (TCO) via inverse electron demand Diels-Alder (iEDDA) chemistry. The disulfide bond (SS) enables controlled release under reducing conditions, making it ideal for precision drug delivery systems like antibody-drug conjugates (ADCs).
Key Features:
- Tetrazine Group: Supports fast, selective iEDDA reactions with TCO-containing molecules.
- Disulfide Bond (SS): Allows for cleavable linkage under reducing conditions, enabling payload release.
- Amine Functionality: Enables coupling with carboxyl groups or activated esters for further modifications.
Tetrazine-Ph-SS-amine Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted cancer therapy.
- Bioconjugation: Attaches biomolecules with high specificity and controlled release.
- Chemical Biology Research: Supports site-specific labeling and protein interaction studies.
This linker ensures precise molecular assembly, controlled drug release, and efficient bioconjugation, making it valuable in therapeutic development and biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
