Vacuolin-1 (CAS 351986-85-1) is a specific inhibitor of Ca²⁺-dependent lysosomal exocytosis. It penetrates the cell and blocks the fusion of lysosomes with the plasma membrane, without affecting other membrane-bound organelles or interfering with endocytic or secretory traffic. This inhibitor is widely used in studies on lysosomal content release and the regulation of autophagy, making it valuable for research in cellular degradation pathways and membrane trafficking.
Key Features:
- Function: Inhibits Ca²⁺-dependent lysosomal exocytosis
- Mechanism: Blocks lysosome fusion with the plasma membrane
- Specificity: Does not affect other organelles or endocytic/secretory traffic
- Applications:
- Studying lysosomal content release
- Modulating autophagy
- Investigating lysosome function and trafficking
- Exploring cellular degradation pathways
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
