Tos-PEG5-Tos CAS:37860-51-8 is a bifunctional PEG derivative with tosyl (tosylate) groups at both ends. The hydrophilic nature of the PEG backbone increases solubility, while the tosyl groups act as efficient leaving groups in nucleophilic substitution reactions. This unique combination enables the formation of stable linkages with a variety of biomolecules, enhancing their properties.
In pharmaceutical research and development, Tos-PEG5-Tos is primarily used as a linker for drug conjugation, facilitating targeted drug delivery systems. By coupling the PEG linker to drug molecules and targeting moieties, the solubility, pharmacokinetics, and biodistribution of drugs are improved, minimizing side effects and increasing therapeutic efficacy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
