Tos-PEG3-CH2CO2H
This product is a PEG linker containing a tosyl (p-toluenesulfonyl) group, a PEG3 spacer, and a terminal carboxyl group. It specifically serves as a versatile intermediate for nucleophilic substitution and amide coupling in bioconjugation and synthesis.
Key Features and Benefits
-
Tosyl Group: Acts as a strong leaving group for nucleophilic substitution.
-
Carboxyl Group: Couples efficiently with amines to form stable amide bonds.
-
PEG3 Spacer: Enhances solubility and reduces steric hindrance.
-
Dual Reactivity: Combines tosyl substitution with carboxyl conjugation.
-
High Purity: Ensures reproducibility in chemical and biological workflows.
Applications
-
Organic Synthesis: Serves as an intermediate for custom PEG derivatives.
-
Bioconjugation: Provides PEGylated scaffolds with substitution and carboxyl functionality.
-
Probe Development: Builds functional probes with dual reactive groups.
-
Drug Delivery: Introduces PEG solubility and reactivity into therapeutic scaffolds.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates tosyl substitution chemistry with carboxyl coupling in a PEG3 scaffold, specifically offering flexibility for synthesis and conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
