THPTA (Trihydroxypropyltriazolylmethylamine)
Short Description
THPTA (Trihydroxypropyltriazolylmethylamine) CAS 760952-88-3 is a highly effective, water-soluble ligand designed to enhance copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. It significantly accelerates the CuAAC process while minimizing interference with physiological conditions, making it ideal for efficient bioconjugation with reduced copper loading and cytotoxicity.
Key Features
- Water-Soluble: Facilitates click chemistry reactions in aqueous environments.
- Highly Potent: Dramatically increases the rate of CuAAC reactions.
- Reduced Copper Loading: Minimizes the amount of copper required, reducing potential cytotoxic effects.
- Low Cytotoxicity: Suppresses cellular toxicity, allowing for safer applications in biological systems.
Applications
- Click Chemistry: Optimizes copper-catalyzed azide-alkyne cycloaddition for efficient labeling and conjugation.
- Bioconjugation: Enhances the coupling of biomolecules with reduced impact on cell viability.
- Chemical Probes: Useful for developing probes that are less likely to interfere with biological processes.
Advantages
- Simplified Reactions: Enables CuAAC to proceed efficiently in water, streamlining experimental procedures.
- Enhanced Efficiency: Increases reaction rates and improves overall outcomes in chemical and biological applications.
- Reduced Toxicity: Lowers the risk of cytotoxicity, making it safer for use in living systems.
Meta Description
Discover THPTA (Trihydroxypropyltriazolylmethylamine), a water-soluble ligand that significantly boosts copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. THPTA enhances click chemistry efficiency, reduces copper loading, and minimizes cytotoxicity, making it ideal for bioconjugation in aqueous environments.
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