Thalidomide-O-PEG2-Acid (CAS number 2488752-64-1) is a synthetic compound that combines a thalidomide-based cereblon ligand with a polyethylene glycol (PEG) linker. This structure is commonly utilized in Proteolysis Targeting Chimeras (PROTACs) to facilitate targeted protein degradation.
Key Features:
- Utilized in Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
- Contains a thalidomide-based cereblon ligand with a PEG2 linker for enhanced flexibility.
- Designed to recruit proteins to E3 ubiquitin ligases, leading to protein ubiquitination and degradation.
- PEG2 linker allows appropriate spacing and flexibility, improving PROTAC molecule efficacy.
- Suitable for biochemical applications requiring high purity (typically ≥98%).
- Compatible with various organic solvents like DMSO and DMF.
Applications:
- Development of PROTACs for research in targeted protein degradation.
- Used in conjugation with target ligands for assembling bifunctional molecules in biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
