TCO-PNP
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) group and a p-nitrophenyl (PNP) ester. It specifically enables rapid tetrazine ligation and efficient amine conjugation, offering compact structure, solubility, and dual reactivity.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via IEDDA bioorthogonal click chemistry.
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PNP Ester: Couples efficiently with primary amines to form stable amide bonds.
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Compact Scaffold: Minimizes steric hindrance while retaining strong reactivity.
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Dual Reactivity: Combines TCO click chemistry with amine conjugation.
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High Purity: Ensures reproducibility in bioconjugation and synthesis workflows.
Applications
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Bioconjugation: Links tetrazine-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with orthogonal handles for targeted therapy.
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Material Science: Functionalizes polymers, nanoparticles, and surfaces with dual chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates rapid tetrazine click chemistry with amine-reactive PNP ester, specifically offering a compact scaffold for multifunctional conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
