TCO-PNP belongs to the class of bioorthogonal chemical reagents. This compound contains a tetrazine functional group (-N4C4) attached to a pyridine ring, making it highly reactive towards trans-cyclooctene (TCO) functional groups. Its unique chemical properties allow for the specific and rapid labeling of TCO-tagged molecules.
The bioorthogonal chemistry enabled by TCO-PNP has revolutionized the field of drug discovery by allowing for the selective and efficient labeling of biomolecules in complex biological systems. By selectively introducing TCO functional groups into drug molecules or biomolecules, researchers can use TCO-PNP to label and track these molecules in real-time in vivo. This allows for the visualization and quantification of drug distribution and targeting, as well as the identification of potential off-target effects.
TCO-PNP has been used in the development of novel drug delivery systems, such as antibody-drug conjugates (ADCs) and nanocarriers. By attaching TCO-PNP to the surface of these carriers, drug molecules can be efficiently and specifically delivered to target cells or tissues.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
