TCO-PEG24-acid
This product is a long-chain linker with a TCO group, PEG24 spacer, and terminal carboxyl. It specifically supports copper-free click chemistry, enhances solubility and flexibility, and provides an amide-coupling handle for bioconjugation and drug delivery.
Key Features and Benefits
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TCO Group: Supports rapid copper-free ligation with tetrazines via IEDDA chemistry.
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PEG24 Spacer: Long, hydrophilic chain enhances solubility and reduces steric hindrance.
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Carboxylic Acid Group: Couples readily with amines to form stable amide linkages.
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Extended Reach: PEG24 spacer provides greater spacing for improved biomolecule accessibility.
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High Purity: Produced to ≥95% purity for reliable and reproducible performance.
Applications
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Bioconjugation: Couples TCO moieties with amines or tetrazine-modified partners.
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Protein and Antibody Labeling: Provides long, flexible spacing for reduced steric effects.
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Drug Delivery: Serves as a linker in PEGylated therapeutics and targeted carriers.
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Probe Development: Builds imaging and diagnostic probes requiring extended linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product combines ultrafast TCO click reactivity with a long PEG spacer and carboxyl group, specifically offering a powerful tool for bioconjugation, probe development, and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
