TCO-PEG1-Biotin
This product is a multifunctional PEG linker containing a trans-cyclooctene (TCO) group, a PEG1 spacer, and a biotin moiety. It specifically enables rapid tetrazine click chemistry and strong streptavidin binding in a compact and soluble scaffold.
Key Features and Benefits
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TCO Group: Reacts rapidly with tetrazines via IEDDA click chemistry.
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Biotin Moiety: Provides strong affinity binding to streptavidin and avidin systems.
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PEG1 Spacer: Offers compact length with solubility enhancement.
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Dual Functionality: Combines bioorthogonal click chemistry with affinity capture.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
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Bioconjugation: Links tetrazine-modified molecules with biotin-binding systems.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides scaffolds with affinity and click handles.
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Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual-reactive groups.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates TCO click chemistry with biotin–streptavidin binding in a PEG1 scaffold, specifically offering a compact and efficient linker.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
