TCO-PEG1-amine
This product is a compact heterobifunctional linker containing a trans-cyclooctene (TCO) group, a short PEG1 spacer, and a terminal amine. The TCO reacts ultrafast with tetrazines via copper-free IEDDA ligation, while the amine couples efficiently with carboxyls or activated esters. The PEG1 chain provides minimal spacing with improved solubility, making this reagent especially ideal for compact conjugation strategies.
Key Features and Benefits
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TCO Group: Performs rapid, copper-free IEDDA ligation with tetrazines.
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Amine Group: Couples readily with carboxyls or NHS esters.
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PEG1 Spacer: Adds hydrophilicity while keeping the scaffold compact.
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Dual Reactivity: Combines orthogonal click chemistry with amine coupling.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links TCO- and amine-reactive biomolecules.
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Protein and Antibody Labeling: Provides dual handles for multifunctional modification.
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Probe Development: Builds compact tetrazine-clickable probes.
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Drug Delivery: Functions as a minimal PEG linker for therapeutic conjugates.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines ultrafast tetrazine reactivity with amine coupling in a compact PEG scaffold, making it especially versatile for conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
