TCO-OH (equatorial)
This product is a strained trans-cyclooctene derivative bearing a terminal hydroxyl group in the equatorial configuration. The TCO moiety enables ultrafast inverse-electron-demand Diels–Alder (IEDDA) click reactions with tetrazines, while the hydroxyl provides a versatile handle for further derivatization, making it especially ideal for bioorthogonal chemistry and probe development.
Key Features and Benefits:
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TCO Group: Highly strained alkene for rapid tetrazine ligation.
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Equatorial Hydroxyl: Provides a reactive site for further chemical modification.
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Bioorthogonal Reactivity: Supports in vitro and in vivo labeling under mild conditions.
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Compact Design: Minimal steric hindrance for efficient conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Click Chemistry: Enables rapid IEDDA reactions with tetrazines for bioorthogonal labeling.
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Bioconjugation: Suitable for site-specific protein, peptide, or antibody modification.
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Probe Development: Useful in imaging agents, diagnostics, and theranostics.
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Synthetic Chemistry: Intermediate for functionalized TCO derivatives.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF, acetonitrile) to maintain TCO stability; avoid prolonged exposure to light and heat.
This product offers ultrafast tetrazine reactivity and a hydroxyl handle in a compact strained alkene framework, making it a especially valuable reagent for bioorthogonal chemistry and advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
