TCO-OH
This product is a strained trans-cyclooctene (TCO) derivative with a terminal hydroxyl group, widely used in bioorthogonal chemistry. The TCO moiety undergoes ultrafast inverse-electron-demand Diels–Alder (IEDDA) reactions with tetrazines, while the hydroxyl group serves as a versatile handle for further derivatization. Its compact, reactive structure makes it especially valuable in bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
-
TCO Moiety: Enables ultrafast, catalyst-free IEDDA click chemistry with tetrazines.
-
Hydroxyl Group: Provides a functional handle for derivatization and conjugation.
-
Compact Structure: Minimizes steric hindrance for efficient labeling.
-
High Reactivity: Supports in vitro and in vivo applications under mild conditions.
-
High Purity: Ensures reproducibility in sensitive chemical biology workflows.
Applications:
-
Bioorthogonal Chemistry: Rapid tetrazine ligation for biomolecule labeling.
-
Bioconjugation: Attaches payloads or probes via hydroxyl modification.
-
Probe Development: Serves as a precursor for fluorescent, radiolabeled, or affinity probes.
-
Drug Delivery: Useful in designing TCO-based linkers for targeted release.
Storage and Handling:
-
Storage: Store at –20 °C, protected from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF); avoid prolonged exposure to light to preserve TCO integrity.
This product combines ultrafast tetrazine reactivity with a versatile hydroxyl group, making it an especially reliable tool for bioorthogonal labeling, conjugation, and therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
