TCO-carbonylamino-benzamido-PEG4 NHS ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for rapid tetrazine ligation and an NHS ester for efficient amine coupling. The PEG4 spacer enhances solubility, flexibility, and spacing, making it specifically used in bioorthogonal labeling and multifunctional bioconjugation.
Key Features and Benefits:
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TCO Group: Enables ultrafast inverse electron-demand Diels–Alder (IEDDA) reactions with tetrazines.
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NHS Ester: Rapidly couples to primary amines for stable amide formation.
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PEG4 Spacer: Provides hydrophilicity, reduced steric hindrance, and moderate spacing.
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Dual Reactivity: Combines bioorthogonal click chemistry with amine-reactive functionality.
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High Purity: Ensures reproducibility in bioconjugation and probe development.
Applications:
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Bioorthogonal Labeling: Supports ultrafast TCO–tetrazine ligation in vitro and in vivo.
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Bioconjugation: Links amine- and tetrazine-modified biomolecules with high selectivity.
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Probe Development: Builds multifunctional imaging or diagnostic probes.
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Drug Delivery: PEGylated scaffold improves solubility and pharmacokinetics of conjugates.
Storage and Handling:
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Storage: Store at –20 °C, tightly sealed and protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light to preserve TCO reactivity.
This product combines ultrafast bioorthogonal reactivity with efficient amine coupling in a compact PEG4 design, making it an especially versatile tool for targeted labeling and advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
