TCO-benzoyl-NHS ester CAS:1233349-56-8 is a chemical compound that is commonly used in bioconjugation and labeling applications. It is composed of several functional groups, including a benzoyl group, a N-hydroxysuccinimide (NHS) ester group, and a TCO (trans-cyclooctene) group.
The benzoyl group is a carbonyl-containing group that is commonly used in organic synthesis. The NHS ester group is an important functional group that is widely used in bioconjugation reactions. This group is highly reactive towards primary amines in biomolecules such as proteins and peptides, allowing for the covalent attachment of molecules to these biomolecules. The TCO group is a strained cyclic alkene that is widely used in bioorthogonal chemistry. This group has a high reactivity towards tetrazine groups, allowing for the formation of covalent bonds between molecules.
In bioconjugation, TCO-benzoyl-NHS ester can be used to attach proteins or peptides to surfaces, nanoparticles, or other molecules. The NHS ester group can react with the primary amines in proteins or peptides, while the TCO group can react with tetrazine groups on surfaces or other molecules. This reaction can be used to create biomaterials or targeted drug delivery systems, allowing for the precise delivery of drugs to specific cells or tissues.
TCO-benzoyl-NHS ester represents an important tool in bioconjugation and labeling applications. By using the reactivity of the NHS ester and TCO groups, this compound allows for the covalent attachment of molecules to biomolecules and surfaces, enabling the creation of new biomaterials and targeted drug delivery systems.
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