TCO-amine hydrochloride
This product is a compact bioorthogonal reagent featuring a trans-cyclooctene (TCO) group for rapid tetrazine ligation and a primary amine in hydrochloride salt form. This design provides excellent solubility, stability, and reactivity, making it especially valuable for bioorthogonal labeling, probe development, and therapeutic applications.
Key Features and Benefits:
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TCO Group: Enables ultrafast, copper-free IEDDA ligation with tetrazines.
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Primary Amine: Couples efficiently with activated esters and electrophiles.
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Hydrochloride Salt: Improves solubility and stability during handling.
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Compact Design: Minimizes steric hindrance in conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioorthogonal Labeling: Provides rapid, catalyst-free conjugation with tetrazine-functionalized partners.
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Probe Development: Builds compact, high-reactivity probes for imaging and diagnostics.
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Drug Delivery: Serves as a linker for targeted, bioorthogonal drug conjugates.
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Bioconjugation: Supports orthogonal coupling strategies with high selectivity.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Dissolve in aqueous or mixed solvents; protect from prolonged light exposure to preserve TCO reactivity.
This product combines a bioorthogonal TCO handle with a stable amine salt, making it an especially versatile reagent for labeling, conjugation, and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
