t-Boc-N-Amido-PEG6-CH2CO2-NHS Ester
This product is a heterobifunctional PEG linker that combines an NHS ester for efficient amine coupling with a protected amine (t-Boc) for later functionalization. As a result, the PEG6 spacer offers excellent aqueous solubility and flexibility, making this reagent ideal for multistep bioconjugation, surface modification, and drug delivery applications.
Key Features and Benefits:
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Amine-Reactive NHS Ester: Enables rapid, stable conjugation with primary amines under mild, aqueous conditions.
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t-Boc-Protected Amine: Allows orthogonal conjugation workflows by protecting the distal amine until needed.
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PEG6 Spacer: Enhances solubility, reduces steric hindrance, and improves biocompatibility.
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Heterobifunctional Design: Facilitates stepwise or selective dual labeling strategies.
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Versatile Applications: Suitable for antibody-drug conjugates (ADCs), nanoparticle functionalization, and surface coating.
Applications:
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Multistep Bioconjugation: Perform selective, sequential labeling of biomolecules and surfaces.
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Surface Functionalization: Modify nanoparticles, biosensors, or polymers with enhanced hydrophilicity and controlled reactivity.
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Targeted Drug Delivery: Use as a linker to assemble modular drug delivery vehicles.
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ADC Development: Incorporate into antibody-drug conjugates for controlled and cleavable drug attachment.
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Polymer and Hydrogel Crosslinking: Introduce reactive sites into polymers for crosslinking or branching.
Storage and Handling:
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Storage: Store at -20°C, away from light and moisture.
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Handling: Use dry, oxygen-free solvents (e.g., DMSO or DMF). Avoid aqueous solutions to prevent NHS hydrolysis.
t-Boc-N-Amido-PEG6-CH2CO2-NHS Ester offers controlled, orthogonal conjugation capabilities through its protected amine and NHS ester groups. Therefore, it is an ideal choice for researchers looking to design flexible, biocompatible, and site-selective bioconjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
