t-Boc-Aminooxy-PEG5-amine
t-Boc-Aminooxy-PEG5-amine is a high-purity PEG linker with a t-Boc-protected aminooxy group and a primary amine. The PEG5 spacer specifically improves solubility, flexibility, and reduces steric hindrance. After Boc deprotection, the aminooxy couples with aldehydes or ketones via oxime ligation, while the amine reacts with carboxylic acids or NHS esters for orthogonal bioconjugation and surface functionalization.
Key Features and Benefits
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Protected Aminooxy Group: t-Boc protection enables controlled deprotection for oxime ligation.
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Primary Amine: Reacts efficiently with carboxyl or NHS ester groups to form stable amide bonds.
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PEG5 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal, site-specific modifications.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Site-specific protein or peptide modification.
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Orthogonal labeling via oxime ligation and amide coupling.
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Surface and nanoparticle functionalization.
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Bioconjugation in drug delivery and diagnostics.
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Multi-step synthesis workflows requiring orthogonal handles.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity and Boc protection.
This product enables orthogonal conjugation through a protected aminooxy group and a primary amine, specifically connected by a PEG5 spacer for solubility and flexibility in advanced bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
