t-Boc-Aminooxy-PEG2-amine
This product is a high-purity PEG linker with a t-Boc-protected aminooxy group and a primary amine. The PEG2 spacer specifically improves solubility, flexibility, and reduces steric hindrance. After Boc deprotection, the aminooxy reacts with aldehydes or ketones via oxime ligation, while the amine couples with carboxylic acids or NHS esters for orthogonal bioconjugation and surface functionalization.
Key Features and Benefits
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Protected Aminooxy Group: t-Boc protection enables controlled deprotection for oxime ligation.
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Primary Amine: Couples efficiently with carboxyl or NHS ester groups to form stable amide bonds.
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PEG2 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal, site-specific conjugations.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Site-specific protein or peptide modification.
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Orthogonal labeling via oxime ligation and amide coupling.
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Nanoparticle and surface functionalization.
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Bioconjugation in drug delivery and diagnostics.
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Multi-step synthesis workflows.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity and Boc protection.
This product combines a protected aminooxy group for aldehyde/ketone ligation and a primary amine for amide coupling, linked by a PEG2 spacer specifically for solubility and flexibility in orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
