SPDP-Val-Cit-PAB-OH
This product is a cleavable linker containing an SPDP disulfide unit, a Val-Cit dipeptide, and a self-immolative PAB spacer with a terminal hydroxyl. It combines redox sensitivity and protease cleavage for controlled payload release, with the hydroxyl group specifically enabling further derivatization.
Key Features and Benefits
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SPDP Moiety: Provides a disulfide bond for reductive cleavage.
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Val-Cit Linker: Protease-sensitive sequence recognized by cathepsin B.
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PAB Spacer: Ensures efficient, self-immolative drug or probe release.
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Terminal Hydroxyl: Offers an additional functionalization site.
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High Purity: Produced to ≥95% purity for reliable research use.
Applications
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Antibody–Drug Conjugates (ADCs): Dual-cleavable design supports targeted drug release.
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Drug Delivery: Builds redox- and protease-sensitive payload carriers.
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Probe Development: Creates cleavable probes for imaging and diagnostics.
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Bioconjugation: Functions as an intermediate for linker–payload construction.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates disulfide and protease-sensitive motifs with a hydroxyl handle, making it an especially versatile tool for ADCs, targeted delivery, and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
