SPDP-PEG6-t-butyl ester CAS:1818294-34-6 is a novel crosslinking reagent designed for selective conjugation, extensively utilized in pharmaceutical research and development. This versatile compound features a bifunctional structure, comprising a cleavable disulfide bond (SPDP) and a hydrophilic polyethylene glycol (PEG6) spacer, which confers enhanced solubility and biocompatibility. The terminal t-butyl ester group offers straightforward thiol-reactive modification, enabling site-specific conjugation of biomolecules, such as proteins, peptides, and antibodies.
In drug delivery systems, the SPDP-PEG6-t-butyl ester serves as an effective linker to create antibody-drug conjugates (ADCs), offering targeted therapy with reduced systemic toxicity. The cleavable disulfide bond facilitates intracellular release of therapeutics, while the PEG6 spacer minimizes immunogenicity and prolongs circulation time. This innovative reagent also finds application in bioconjugate chemistry, immobilization, and affinity purification, accelerating the development of novel therapeutics and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
