SPDP-C6-Sulfo-NHS Ester (CAS: 169751-10-4)
SPDP-C6-Sulfo-NHS Ester is a water-soluble, heterobifunctional crosslinker designed for bioconjugation. It contains a Sulfo-NHS ester that reacts with primary amines and a pyridyldithiol group that forms reversible disulfide bonds with sulfhydryl groups. The C6 spacer arm adds flexibility and reduces steric hindrance during conjugation reactions.
Key Features:
- Functional Groups:
- Sulfo-NHS Ester: Reacts with primary amines on biomolecules.
- Pyridyldithiol Group: Forms reversible disulfide bonds with thiols.
- C6 Spacer Arm: Increases flexibility and reduces steric hindrance.
- Water Solubility: Easily dissolves in aqueous solutions for efficient conjugation.
Applications:
- Protein-Protein Conjugation: Links proteins and peptides through reversible disulfide bonds.
- Antibody-Drug Conjugates (ADCs): Acts as a linker for targeted drug delivery.
- Surface Modification: Functionalizes biomaterials with both amine and thiol groups.
Handling and Storage:
- Molecular Formula: C₁₈H₂₂N₃NaO₈S₃
- Molecular Weight: 527.56 g/mol
- Storage: Store at -20°C, protected from light and moisture.
This product is widely used in research for crosslinking and bioconjugation applications, offering flexibility, water solubility, and reversible binding.
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