SPDP acid
This product is a thiol-cleavable linker containing a reactive pyridyldithiol group and a terminal carboxylic acid. The pyridyldithiol moiety enables reversible disulfide exchange with thiols, while the carboxyl group couples readily with amines or activated esters for stable amide bond formation. This compact, cleavable design makes SPDP acid a versatile tool specifically for controlled bioconjugation, protein modification, and drug delivery research.
Key Features and Benefits
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Pyridyldithiol Group: Forms disulfides with thiols, cleavable under reducing conditions.
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Carboxylic Acid Group: Couples efficiently with amines to form amide bonds.
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Cleavable Linkage: Allows reversible conjugation for controlled release.
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Compact Structure: Minimal spacer length for efficient incorporation.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Protein Modification: Attaches biomolecules via thiol-disulfide exchange.
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Bioconjugation: Links amine- and thiol-functionalized partners with a cleavable bond.
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Drug Delivery: Builds controlled-release linkers for therapeutic design.
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Probe Development: Creates disulfide-cleavable probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use freshly prepared solutions; avoid prolonged exposure to aqueous buffers.
This product combines a cleavable disulfide handle with a reactive carboxyl group in a compact framework, specifically offering versatility for reversible conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
