Propargyl-PEG8-amine
This product is a heterobifunctional linker containing a terminal propargyl (alkyne) group, an eight-unit PEG spacer, and a primary amine. The alkyne enables copper-catalyzed (CuAAC) or copper-free click chemistry with azides, while the amine couples efficiently with carboxyls or activated esters. The PEG8 spacer provides excellent solubility, flexibility, and spacing, making this reagent especially versatile for bioconjugation and probe development.
Key Features and Benefits
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Propargyl Group: Supports CuAAC or SPAAC click reactions with azides.
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Primary Amine: Couples readily with carboxyls or NHS esters for amide formation.
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PEG8 Spacer: Enhances solubility, flexibility, and accessibility in conjugation.
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Dual Reactivity: Enables orthogonal bioconjugation strategies.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Couples azide- and carboxyl-modified biomolecules in one linker system.
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Protein and Antibody Labeling: Provides orthogonal handles for selective modifications.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Serves as a linker for PEGylated therapeutics and nanocarriers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product combines an alkyne click handle with amine reactivity on a long, flexible PEG8 spacer, making it an especially excellent tool for multifunctional conjugation in chemical biology and therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
