Propargyl-PEG6-NHS ester
This PEG6 linker features a propargyl group for click chemistry and an NHS ester for rapid amine coupling. The PEG6 chain adds hydrophilicity and flexibility, making it especially ideal for dual-functional bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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Propargyl Group: Supports CuAAC and SPAAC click chemistry with azides.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG6 Spacer: Provides solubility, flexibility, and balanced steric spacing.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Combines click chemistry with amine-reactive functionality for orthogonal use.
Applications:
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Bioconjugation: Enables dual labeling of proteins, peptides, and biomolecules.
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Click Chemistry: Supports azide–alkyne ligation for probe and imaging agent development.
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Drug Delivery: PEGylated linker enhances solubility, stability, and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, polymers, and biomaterials with dual handles.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain NHS and alkyne stability.
This product offers click-ready and amine-reactive groups in a medium PEG spacer, making it an especially versatile reagent for conjugation, drug delivery, and advanced probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
