Propargyl-PEG6-amine CAS:1198080-04-4 is a versatile, bifunctional polyethylene glycol (PEG) derivative with a propargyl group on one end and an amine group on the other. It serves as an essential linker in pharmaceutical research and development due to its biocompatibility, water solubility, and reduced immunogenicity.
The propargyl group enables facile click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating targeted drug delivery and bioconjugation of active pharmaceutical ingredients (APIs). The amine terminus allows for straightforward conjugation to carboxylic acid or isothiocyanate-containing moieties. Propargyl-PEG6-amine’s hydrophilic nature enhances solubility and stability of conjugated drugs, improving pharmacokinetic properties, reducing aggregation, and minimizing nonspecific interactions.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
