Propargyl-PEG4-5-nitrophenyl carbonate linker contains a propargyl group and nitrophenyl group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. nitrophenyl carbonate can be conjugated to the amino group of lysine by means of stable carbamate linkages. The PEG spacer increases the aqueous solubility of the resulting compound.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.