Propargyl-PEG2-amine
This product is a bifunctional PEG linker with a terminal propargyl group, a PEG2 spacer, and a primary amine. It specifically enables copper-catalyzed or copper-free click chemistry with azides and amide coupling through the amine group.
Key Features and Benefits
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Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
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Primary Amine: Couples efficiently with carboxyls, NHS esters, and activated linkers.
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PEG2 Spacer: Enhances solubility while maintaining compact molecular length.
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Dual Reactivity: Provides orthogonal handles for click and amine conjugation.
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High Purity: Ensures reproducible results in sensitive workflows.
Applications
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Bioconjugation: Links azide-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEGylated scaffolds with dual conjugation handles.
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Organic Synthesis: Serves as a versatile intermediate for custom linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates alkyne click chemistry and amine reactivity in a PEG2 scaffold, specifically offering a compact and versatile linker for conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
