propargyl-PEG12-amine is a PEG crosslinker with a propargyl and an amine group on the ends. The amine group readily reacts with activated NHS esters and carboxylic acids under coupling conditions to form stable amide bonds. It can also react with carbonyl groups such as ketone, aldehyde via reductive amination condition. The terminal alkine group reacts with azide-bearing molecules via copper catalyzed Click Chemistry to form a stable triazole linkage. The increasing aqueous solubility derived from the PEG spacer makes it an ideal conjugation linker for biological applications.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.