Pomalidomide-PEG3-Acid CAS:2138440-82-9 is a small molecule linker that is commonly used in drug development. It is composed of three functional groups: Pomalidomide, a potent immunomodulatory agent, PEG3 (polyethylene glycol), a flexible and biocompatible linker, and an acid group, which can be used for conjugation to other molecules.
The Pomalidomide portion of the molecule is an immunomodulatory agent that is used to treat multiple myeloma and other hematologic malignancies. It works by binding to cereblon, a component of the E3 ubiquitin ligase complex, leading to the degradation of specific transcription factors and subsequent anti-tumor effects. The PEG3 linker provides flexibility and solubility to the molecule, allowing it to be used in various drug delivery applications.
The acid group in Pomalidomide-PEG3-Acid can be used to link the molecule to other molecules or materials, such as small molecules, peptides, or polymers. This linking can be achieved through various chemical reactions, such as amide bond formation, esterification, or thiol-ene coupling, depending on the functional groups present on the other molecule. This linking strategy enables the targeted delivery of drugs to specific tissues or cells, thereby improving drug efficacy and minimizing side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
