Pentanamide, 5-azido-N-[4-(2-cyanoethynyl)-phenyl]
Pentanamide, 5-azido-N-[4-(2-cyanoethynyl)-phenyl] is a high-purity heterobifunctional reagent featuring an azide group for copper-catalyzed (CuAAC) or strain-promoted (SPAAC) click chemistry and a cyanoethynyl moiety for cycloaddition or further derivatization. The pentanamide backbone specifically provides structural stability and a suitable linker length for efficient spatial positioning in conjugation reactions. This reagent is especially ideal for orthogonal labeling, probe synthesis, and advanced chemical biology applications.
Key Features and Benefits
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Azide Group: Compatible with CuAAC and SPAAC click chemistry for selective conjugation with alkynes.
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Cyanoethynyl Group: Offers unique reactivity for cycloaddition and functional probe design.
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Amide Linker: Provides stability and defined spacing between reactive groups.
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Orthogonal Design: Supports multi-step, site-specific modifications.
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High Purity: Supplied at >95% purity for reproducibility.
Applications
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Orthogonal chemical labeling strategies.
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Synthesis of multifunctional molecular probes.
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Bioconjugation for chemical biology and diagnostics.
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Nanoparticle and polymer functionalization.
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Medicinal chemistry research for linker design.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents; avoid moisture to maintain reactivity.
This product combines azide click chemistry and cyanoethynyl reactivity in a stable amide-linked scaffold for orthogonal bioconjugation and probe synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.