PEG8-Tos linker bears a hydroxyl group and a tosyl group. The PEG spacer increases the aqueous solubility of the resulting compound. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution.
PEG8-Tos is a water-soluble derivative of tosyl chloride (TosCl) that has been modified with an eight-carbon polyethylene glycol chain attached to it. It is used in organic synthesis as a coupling reagent to join two molecules together, such as two amino acids to form a peptide.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
