PEG8-Tos
This PEG8 linker has a tosyl leaving group and a hydroxyl group connected by an eight-unit PEG chain, offering hydrophilicity, flexibility, and efficient substitution for bioconjugation and synthesis.
Key Features and Benefits:
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Tosyl Group: Excellent leaving group for nucleophilic substitution reactions.
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Hydroxyl Group: Provides a versatile site for further derivatization.
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PEG8 Spacer: Ensures solubility, flexibility, and steric accessibility.
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High Purity: Enables reproducibility in complex conjugation workflows.
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Versatile Design: Useful as an intermediate for linker and scaffold synthesis.
Applications:
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Bioconjugation: Serves as a functional intermediate for biomolecule modification.
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Drug Delivery: PEGylated scaffold enhances solubility, stability, and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and biomaterials.
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Synthetic Chemistry: Intermediate for preparing amines, azides, or thiol derivatives from tosyl substitution.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture-free container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) for substitution; avoid prolonged exposure to moisture.
This product provides an extended PEG chain with a tosyl leaving group, making it an especially versatile intermediate for nucleophilic substitution, conjugation, and scaffold design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
