PEG6-Tos
This product is a tosyl-activated PEG derivative with a six-unit polyethylene glycol chain terminated by a tosyl (p-toluenesulfonyl) group. The tosyl group serves as a highly reactive leaving group, allowing nucleophilic substitution with amines, thiols, or alkoxides. The PEG6 spacer improves solubility, flexibility, and accessibility, making this reagent an especially versatile intermediate for PEGylation, surface modification, and advanced synthesis.
Key Features and Benefits
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Tosyl Group (Tos): Excellent leaving group for substitution with nucleophiles.
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PEG6 Spacer: Provides hydrophilicity, flexibility, and reduced steric hindrance.
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Versatile Intermediate: Converts into PEG-amines, PEG-thiols, and other PEG derivatives.
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Improved Solubility: PEG chain enhances aqueous and organic compatibility.
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High Purity: Produced to ≥95% purity for reproducible performance.
Applications
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PEG Derivatization: Precursor for multifunctional PEG linkers and building blocks.
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Bioconjugation: Enables PEGylation of biomolecules for stability and solubility.
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Surface Modification: Functionalizes polymers, nanoparticles, and materials to improve biocompatibility.
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Organic Synthesis: Acts as a versatile scaffold for advanced PEG chemistry.
Storage and Handling
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Storage: Store at –20 °C in a tightly sealed container, away from moisture and light.
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Handling: Use under inert atmosphere when possible; prepare fresh solutions before use.
This product combines a tosyl leaving group with a PEG6 spacer, specifically offering a flexible and solubilizing platform for substitution, PEGylation, and conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
