PEG21-Tos
This product is a tosyl-activated polyethylene glycol derivative with a 21-unit PEG chain terminated by a tosyl (p-toluenesulfonyl) group. The PEG21 backbone provides excellent solubility and flexibility, while the tosyl group serves as a highly reactive leaving group for nucleophilic substitution, making it a versatile intermediate for preparing amine-, thiol-, or hydroxyl-functionalized PEG derivatives.
Key Features and Benefits
-
Tosyl Group (Tos): Functions as an excellent leaving group for substitution with nucleophiles such as amines, thiols, and alkoxides.
-
PEG21 Spacer: Provides long-chain hydrophilicity, flexibility, and enhanced solubility in aqueous and organic media.
-
Synthetic Versatility: Acts as a key intermediate for a wide range of PEG-functionalized molecules.
-
High Reactivity: Facilitates efficient conversions under mild reaction conditions.
-
High Purity: Produced to ≥95% purity for reliable and reproducible synthesis.
Applications
-
PEG Derivatization: Converts into PEG-functionalized reagents, including PEG-amines, PEG-thiols, and PEG-alcohols.
-
Bioconjugation: Serves as a precursor for linkers in drug delivery and probe design.
-
Surface Modification: Functionalizes nanoparticles, polymers, and materials to enhance biocompatibility.
-
Organic Synthesis: Provides a versatile starting material for advanced PEG intermediates.
Storage and Handling
-
Storage: Store at –20 °C in a dry, sealed container, away from light and moisture.
-
Handling: Use under inert atmosphere when possible; dissolve freshly before reaction.
This product combines the reactivity of a tosyl group with the solubilizing properties of a long PEG21 chain, making it an especially valuable intermediate for PEGylation and advanced bioconjugation chemistry.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
