PEG10-Tos
This product is a monofunctional PEG linker containing a tosyl (p-toluenesulfonyl) reactive group and a PEG10 spacer. The tosyl group acts as an excellent leaving group, specifically enabling nucleophilic substitution for the preparation of custom PEG derivatives and functional linkers.
Key Features and Benefits
-
Tosyl Group: Highly effective leaving group for substitution with amines, thiols, or alkoxides.
-
PEG10 Spacer: Enhances solubility and provides flexible spacing.
-
Reactive Intermediate: Serves as a precursor for functionalized PEG-based linkers.
-
Extended Length: PEG10 provides increased hydrophilicity and reduced steric hindrance.
-
High Purity: Ensures reproducibility in sensitive synthesis and bioconjugation workflows.
Applications
-
Organic Synthesis: Prepares functional PEG derivatives via nucleophilic substitution.
-
Bioconjugation: Builds PEGylated linkers for proteins, peptides, or small molecules.
-
Material Science: Introduces PEG functionality into polymers or nanostructures.
-
Drug Delivery: Constructs PEG scaffolds for enhanced solubility and stability.
Storage and Handling
-
Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product combines a tosyl leaving group with a PEG10 spacer, specifically providing a reactive and soluble intermediate for linker synthesis, bioconjugation, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
