PEG10 (CAS 5579-66-8)
PEG10, also known as Decaethylene Glycol or HO-PEG10-OH, is a linear polyethylene glycol compound with 10 ethylene glycol units. Thanks to its high biocompatibility and versatility, it is widely used across pharmaceutical, biochemical, and industrial fields.
Key Properties
- Chemical Formula: C₂₀H₄₂O₁₁
- Molecular Weight: 458.55 g/mol
- Structure: Linear chain of 10 ethylene glycol units, terminated by hydroxyl (-OH) groups on both ends.
- Appearance: Clear, viscous liquid
- Purity: ≥95%
- Solubility: Completely soluble in water and in organic solvents like ethanol, methanol, and acetone.
- Melting Point: ~28°C
- Boiling Point: ~280°C at 7 mmHg pressure.
- Density: ~1.115 g/cm³
Applications
1. Bioconjugation and Linker Chemistry
Firstly, PEG10 is widely used as a flexible linker in protein conjugation and the synthesis of PROTACs (proteolysis-targeting chimeras). Additionally, it enhances solubility, bioavailability, and flexibility, making it indispensable in molecular interactions.
2. Pharmaceuticals
In pharmaceutical formulations, PEG10 plays a key role in improving the solubility of hydrophobic drugs. Furthermore, it stabilizes sensitive compounds, preventing issues such as aggregation or degradation.
3. Research and Development
Notably, PEG10 is a valuable tool in protein labeling, allowing for the attachment of fluorescent tags, biotin, or other markers. Moreover, it supports assay development, enabling precise molecular detection.
4. Surface Modification
When it comes to material science, PEG10 excels in improving the biocompatibility of nanoparticles, hydrogels, and polymers. Beyond that, it minimizes non-specific protein binding, which is critical for many biomedical applications.
5. Industrial Uses
Finally, in the industrial sector, PEG10 serves as a stabilizer in cosmetics and personal care products. In addition, it acts as a dispersant and lubricant in various processes.
Benefits
- Biocompatibility: Firstly, PEG10 is safe for biological and pharmaceutical use.
- Hydrophilicity: It significantly enhances the solubility of hydrophobic molecules in water-based systems.
- Stability: Furthermore, it remains stable across a wide range of pH and temperature conditions.
- Versatility: Its diverse applications make it ideal for scientific and industrial purposes alike.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
