Oleic-DBCO
This product is a lipid–click chemistry conjugate containing an oleic acid chain linked to dibenzocyclooctyne (DBCO). It specifically enables copper-free click chemistry with azides while incorporating a hydrophobic tail for membrane anchoring or lipid–PEG conjugation.
Key Features and Benefits
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DBCO Group: Reacts rapidly with azides via strain-promoted azide–alkyne cycloaddition (SPAAC).
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Oleic Acid Moiety: Provides hydrophobicity and lipid membrane anchoring.
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Copper-Free Chemistry: Eliminates cytotoxic catalysts, suitable for biological systems.
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Dual Functionality: Combines lipid anchoring with bioorthogonal reactivity.
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High Purity: Ensures reproducibility in chemical biology and materials research.
Applications
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Bioconjugation: Links azide-modified biomolecules to lipid-based systems.
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Probe Development: Builds lipid–click probes for imaging and diagnostics.
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Drug Delivery: Functionalizes liposomes, micelles, or nanoparticles with DBCO handles.
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Membrane Studies: Anchors click-ready groups into lipid bilayers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Dissolve in anhydrous organic solvents such as chloroform, DCM, or ethanol; avoid prolonged exposure to air and light.
This product integrates lipid hydrophobicity with copper-free click reactivity, specifically offering a versatile tool for membrane anchoring, drug delivery, and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.