OH-PEG-SC or HO-PEG-NHS with a molecular weight of 6K are PEG derivatives designed for conjugation to amine-containing biomolecules. OH-PEG-SC features a succinimidyl carbonate (SC) group, while HO-PEG-NHS contains an N-hydroxysuccinimide (NHS) ester. Both of these groups are highly reactive with amines, making them ideal for bioconjugation, drug delivery, and surface modification. The PEG chain (MW 6K) enhances solubility, improves stability, and reduces immunogenicity.
Applications:
- Bioconjugation:
The SC and NHS groups react with primary amines on proteins, peptides, and other biomolecules, allowing for efficient and stable conjugation in therapeutic and diagnostic applications. - Drug Delivery:
The PEGylation increases solubility and prolongs circulation time in the bloodstream. This makes it valuable for enhancing drug stability and reducing immune responses. - Surface Modification:
Used to modify the surfaces of nanoparticles, hydrogels, and medical devices, improving biocompatibility and preventing non-specific binding.
Conclusion:
OH-PEG-SC and HO-PEG-NHS (MW 6K) are essential tools for bioconjugation, drug delivery, and surface modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
