OH-PEG-SC (or HO-PEG-NHS) with a molecular weight of 5000 is a hydroxyl-terminated PEG modified with succinimidyl carbonate (SC) or N-hydroxysuccinimide (NHS) ester. These reactive groups allow for easy conjugation to primary amines, making it ideal for various applications. The PEG chain improves solubility, reduces immunogenicity, and enhances biocompatibility.
Key Applications:
- Bioconjugation:
The NHS or SC groups readily bond with amine-containing molecules like proteins or peptides. This helps create stable conjugates, which are important in therapeutic and diagnostic contexts. - Drug Delivery:
The PEG chain enhances drug solubility and stability. Moreover, it helps minimize immune responses and increases drug circulation time, making it useful for more effective drug delivery systems. - Surface Modification:
OH-PEG-SC / HO-PEG-NHS is often used to modify surfaces, such as those of nanoparticles or medical devices. This modification helps prevent non-specific binding while improving the overall biocompatibility of the material.
Conclusion:
In summary, OH-PEG-SC / HO-PEG-NHS (MW 5000) is highly effective for bioconjugation, drug delivery, and surface modification. Its reactive groups ensure easy amine conjugation, while the PEG chain improves both solubility and biocompatibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
