Norbornene-PEG5 azide is a highly functional polyethylene glycol (PEG) linker specifically designed for bioconjugation and material modifications. More importantly, it features a norbornene group that enables bio-orthogonal reactions and an azide group that supports click chemistry. Additionally, the PEG5 spacer significantly enhances solubility, reduces steric hindrance, and improves flexibility. As a result, Norbornene-PEG5 azide becomes a valuable choice for applications in drug delivery, surface modification, and bioconjugation.
Key Features
- Dual Functional Groups – Notably, the norbornene group supports bio-orthogonal reactions, while the azide group enables click chemistry, offering broad utility.
- PEG5 Spacer – Furthermore, it improves solubility, lowers steric hindrance, and increases flexibility, making conjugation more efficient.
- High Biocompatibility – This feature minimizes immunogenicity and ensures excellent compatibility with biological systems.
- Versatile Reactivity – Because of its adaptability, it works seamlessly in pharmaceuticals, biotechnology, and material science.
- Improved Hydrophilicity – In addition, it enhances dispersion in aqueous environments, making it especially suitable for biomedical applications.
Applications
- Bioconjugation and Labeling – Enables efficient attachment of biomolecules such as proteins, peptides, and antibodies, which is crucial for biological studies.
- Targeted Drug Delivery – Plays a vital role in enhancing drug solubility and ensuring controlled release for improved therapeutic effects.
- Surface and Nanoparticle Functionalization – Additionally, it improves biointerface properties, making it ideal for biosensors and nanomedicine.
- Click Chemistry Reactions – Allows for fast and highly selective conjugation via CuAAC or SPAAC, streamlining complex modifications.
- Hydrogel and Biomaterial Development – Furthermore, it supports the creation of biofunctional hydrogels for medical and tissue engineering applications.
Conclusion
In summary, Norbornene-PEG5 azide is a powerful and versatile PEG linker that effectively bridges bio-orthogonal and click chemistry reactions. With its norbornene and azide functional groups, along with a flexible PEG5 spacer, it provides excellent solubility, biocompatibility, and reactivity. Consequently, this makes it an essential tool for applications in drug delivery, bioconjugation, and material science. Therefore, researchers can confidently rely on it to advance biomedical and chemical innovations.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
