Norbornene-PEG4 azide

Norbornene-PEG4 azide (CAS: 2740552-50-3) is a highly effective reagent that provides exceptional reliability in bio-orthogonal chemistry and click reactions. It contains two key functional groups: first, the norbornene, which enables strain-promoted azide-alkyne cycloaddition (SPAAC), and second, the azide (-N₃), which allows for copper-catalyzed click chemistry (CuAAC). Additionally, its PEG4 linker dramatically enhances solubility and biocompatibility, making it much easier to use in biological environments. Because of these unique properties, this reagent is widely applied in drug delivery research, biomolecule labeling, and nanotechnology.

Key Features

• Two Reactive Groups – Norbornene enables SPAAC, while azide facilitates CuAAC, ensuring superior flexibility.
• Highly Selective Reactions – Ensures efficient bio-orthogonal chemistry while minimizing unwanted side effects.
• Water-Soluble PEG4 Linker – Dramatically improves solubility and reduces steric hindrance for better performance.
• Versatile Applications – Works seamlessly in biomolecule labeling, drug delivery, and nanotechnology.
• Stable & Reliable – Delivers strong, consistent, and reproducible results across various applications.

Applications

• Click Chemistry Reactions – Works efficiently in CuAAC and SPAAC, enabling highly precise bioconjugation.
• Protein & Peptide Labeling – Modifies biomolecules with ease, enhancing detection and functionalization.
• Surface Functionalization – Optimizes surface properties, making it ideal for biomedical applications.
• Targeted Drug Delivery – Supports the development of innovative and highly effective drug delivery systems.
• Nanoparticle Engineering – Enhances nanoparticle stability, improving their functionality and performance.

Conclusion

To sum up, Norbornene-PEG4 azide serves as an excellent choice for bio-orthogonal chemistry and click chemistry applications. Not only does it provide both copper-catalyzed and strain-promoted reaction capabilities, but it also ensures highly efficient and selective modifications. Furthermore, its PEG4 linker enhances solubility, making it easier to use across different research applications. Whether for bioconjugation, drug delivery, or nanotechnology, this reagent consistently delivers strong performance and reliable results.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.