N-Mal-N-bis(PEG4-amine) TFA salt
This product is a multifunctional PEG-based linker featuring a maleimide group for thiol-selective conjugation and two primary amines, supplied as a trifluoroacetic acid (TFA) salt for enhanced stability and solubility. The PEG4 spacers provide hydrophilicity and flexibility, making it an especially ideal reagent for orthogonal bioconjugation, protein modification, and advanced material science.
Key Features and Benefits:
-
Maleimide Group: Reacts selectively with thiols to form stable thioether linkages.
-
Dual Amine Groups: Enable efficient amide bond formation with carboxyls and NHS esters.
-
PEG4 Spacers: Provide hydrophilicity, reduced steric hindrance, and versatile spacing.
-
TFA Salt Form: Improves compound stability and handling.
-
Multifunctional Reactivity: Supports orthogonal and multistep conjugation strategies.
Applications:
-
Bioconjugation: Facilitates dual amine coupling alongside thiol-specific modification.
-
Protein Crosslinking: Bridges thiol- and amine-containing biomolecules.
-
Drug Delivery: PEGylated linker improves solubility, stability, and circulation time.
-
Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels with multifunctional handles.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain amine and maleimide reactivity.
This product combines thiol reactivity with dual amine functionality in a stable, hydrophilic framework, making it an especially excellent tool for multifunctional conjugation and biomolecule engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
