N-DBCO-N-bis(PEG2-NHS ester) (CAS: 2128735-29-3) is a PEG-based linker with a DBCO group and two NHS ester termini. The DBCO moiety supports copper-free click chemistry with azide-containing compounds, ensuring efficient bioconjugation. The NHS esters react with primary amines, such as those on lysine residues in proteins, to form stable amide bonds. This linker is valuable for creating antibody-drug conjugates (ADCs), targeted drug delivery systems, and other applications requiring stable biomolecule linkage.
Key Features:
- DBCO Functional Group: Enables copper-free click chemistry with azides, reducing cytotoxicity.
- NHS Ester Termini: Reacts with primary amines to form stable amide bonds.
- PEG2 Spacer: Increases solubility and flexibility, reducing steric hindrance.
Applications:
- Bioconjugation: Attaches biomolecules for research and therapeutic uses.
- Antibody-Drug Conjugates (ADCs): Acts as a linker for targeted delivery of cytotoxic agents.
- Targeted Drug Delivery: Supports the development of systems that require precise linkage of drugs and targeting ligands.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
