N-DBCO-N-bis(PEG2-acid) (CAS: 2110449-00-6) is a branched PEG linker with a DBCO group and two PEG2-acid chains. The DBCO group allows copper-free click reactions with azides, making bioconjugation efficient and reducing cytotoxicity. The carboxylic acid ends enable further functionalization by forming amide bonds with primary amines using activators like EDC or HATU.
Key Features:
- DBCO Group: Supports copper-free click chemistry with azides.
- Branched PEG Structure: Enhances solubility and flexibility, reducing steric hindrance.
- Increased Functional Group Density: Supports multivalent binding and higher payload capacity, ideal for applications needing multiple conjugation sites.
- Carboxylic Acid Ends: Allow versatile conjugation through amide bonds.
Applications:
- Bioconjugation: Links proteins, peptides, and small molecules for research or therapy.
- Antibody-Drug Conjugates (ADCs): Acts as a linker for targeted drug delivery.
- Targeted Drug Delivery: Helps create stable, precise drug delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
