N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide

N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)bicyclo[2.2.1]hept-5-ene-2-carboxamide

This product is a heterobifunctional linker containing a terminal amine and a norbornene group specifically connected by a hydrophilic PEG-like chain. The amine enables coupling with activated carboxyls or NHS esters, while the norbornene provides bioorthogonal reactivity in inverse electron-demand Diels–Alder (IEDDA) click chemistry with tetrazines.

Key Features and Benefits:

• Terminal Amine: Reacts with carboxyls, NHS esters, and other electrophiles.

• Norbornene Group: Enables fast, selective IEDDA click chemistry with tetrazines.

• PEG-like Spacer: Improves solubility, flexibility, and reduces steric hindrance.

• High Purity: Suitable for sensitive and reproducible conjugation workflows.

• Bioorthogonal Reactivity: Compatible with aqueous and complex biological systems.

Applications:

• Bioconjugation: Site-specific conjugation through amine and norbornene reactivity.

• Click Chemistry: IEDDA ligation with tetrazines for rapid, bioorthogonal labeling.

• Drug Delivery: Incorporate into linker-payload designs for targeted therapeutics.

• Surface Modification: Functionalize nanoparticles, hydrogels, or polymers.

Storage and Handling:

• Storage: Store at –20 °C, away from light and moisture.

• Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain integrity of both functional groups.

This reagent combines amine functionality with norbornene-based click chemistry, offering a versatile tool for orthogonal and bioorthogonal conjugation strategies.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.