Mitomycin C (CAS: 50-07-7)
Product Overview
Mitomycin C is a potent antitumor antibiotic derived from Streptomyces species. It acts as a DNA crosslinker, inhibiting DNA synthesis and causing cytotoxicity in rapidly dividing cells. Widely used in cancer therapy and research, Mitomycin C is particularly effective against hypoxic tumor cells due to its ability to generate reactive oxygen species under low oxygen conditions.
Features
- Mechanism of Action: Inhibits DNA synthesis via alkylation and crosslinking.
- Broad Antitumor Activity: Effective against various solid tumors, especially in hypoxic conditions.
- High Potency: Requires low concentrations for significant cytotoxic effects.
- Stable Formulation: Available in lyophilized powder for extended shelf life.
Applications
- Cancer Therapy: Used in clinical treatments for gastric, pancreatic, and bladder cancers.
- Research Tool: Investigates mechanisms of DNA damage and repair.
- Ophthalmology: Prevents scar tissue formation in glaucoma surgery.
- Cell Biology Studies: Examines cytotoxic effects on proliferating cells.
Technical Details
- Chemical Formula: C₁₅H₁₈N₄O₅
- Molecular Weight: 334.33 g/mol
- Purity: ≥98%
- Solubility: Soluble in water and DMSO.
- Storage: Store at 2-8°C in a dry, light-protected environment.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
