Methyltetrazine-PEG4-NH-Boc
This product is a bifunctional PEG linker containing a methyltetrazine group, a PEG4 spacer, and a Boc-protected amine. It enables rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry with trans-cyclooctene (TCO) and specifically provides an orthogonal Boc-protected amine for selective conjugation.
Key Features and Benefits
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Methyltetrazine Group: Reacts rapidly with TCO in bioorthogonal click chemistry.
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PEG4 Spacer: Improves solubility and reduces steric hindrance.
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Boc-Protected Amine: Allows controlled deprotection for selective amine conjugation.
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Dual Functionality: Combines click reactivity with protected amine chemistry.
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High Purity: Ensures reproducible results in sensitive workflows.
Applications
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Bioconjugation: Links TCO-modified biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEGylated scaffolds with orthogonal chemistries.
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Material Science: Functionalizes polymers and nanoparticles with dual handles.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product combines methyltetrazine–TCO click reactivity with a Boc-protected amine in a PEG4 scaffold, offering an especially versatile linker for bioconjugation and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
