Methyltetrazine-PEG12-Maleimide
Description:
Methyltetrazine-PEG12-Maleimide is a functional linker combining a methyltetrazine group, a PEG12 (polyethylene glycol) spacer, and a maleimide group. The methyltetrazine group allows for strain-promoted click chemistry with trans-cyclooctene (TCO)-functionalized molecules, while the maleimide group reacts specifically with thiol groups on biomolecules. The PEG12 spacer enhances solubility and flexibility, making it an ideal choice for bioconjugation applications in complex biological systems.
Key Features:
- Methyltetrazine Group: Enables copper-free, strain-promoted click chemistry with TCO, allowing specific and rapid conjugation.
- Maleimide Group: Reacts with thiol groups on biomolecules, such as cysteine residues, for stable covalent attachment.
- PEG12 Spacer: Increases solubility, flexibility, and reduces steric hindrance, enhancing compatibility in biological environments.
Applications:
- Bioconjugation: Useful for creating stable conjugates in biological studies, such as protein and antibody modifications.
- Targeted Drug Delivery: Enables precise attachment of therapeutic agents to biomolecules for targeted delivery.
- Live-Cell Imaging and Diagnostics: Suitable for bioorthogonal labeling in live cells, enhancing imaging and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
