Methylcyclopropene-NHS Carbonate is a small molecule linker that contains several functional groups, including a carbonate group, a nitrogen-hydrogen-sulfur (NHS) ester group, and a cyclopropene group. This compound is commonly used in the field of bioconjugation, which involves the covalent attachment of two or more molecules to form a complex that retains the properties of each individual component.
The carbonate group in Methylcyclopropene-NHS Carbonate is particularly useful, as it can be used to attach the compound to other molecules, such as proteins or peptides, through a nucleophilic substitution reaction. The NHS ester group can react with primary amines in the target molecules, such as lysine residues or N-terminal amines, to form stable amide bonds. The cyclopropene group, on the other hand, can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with azides, a widely used bioorthogonal reaction that enables selective labeling and detection of biomolecules.
Methylcyclopropene-NHS Carbonate is a versatile linker that can be used to modify the surface of various biomolecules, such as proteins, peptides, or antibodies, enabling targeted delivery to specific cells or tissues. This modification can improve the pharmacokinetics and efficacy of drugs, as well as reduce their toxicity and immunogenicity. Its unique combination of functional groups make it an essential tool in drug discovery and development, and a promising candidate for the development of targeted therapeutics in various diseases.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
