Methylamino-PEG5-azide CAS:2055046-24-5 is a chemical compound that contains several functional groups, each with its own unique role in drug delivery and bioconjugation. The PEG (polyethylene glycol) chain in Methylamino-PEG5-azide improves the solubility and stability of drugs, while reducing their clearance by the body’s immune system. This makes PEGylation an effective approach for increasing the half-life of drugs, as well as reducing their toxicity and immunogenicity.
The azide functional group in Methylamino-PEG5-azide is used for bioconjugation, allowing it to react with alkyne or cyclooctyne groups to form stable triazole linkages. This enables the conjugation of drugs or nanoparticles with targeting moieties, such as antibodies or peptides, which can improve their delivery to specific cells or tissues.
The methylamino group in Methylamino-PEG5-azide serves as a protecting group during synthesis, which can be removed under mild conditions to reveal the free amine group. The amine group is a common functional group in drugs and biomolecules, making it a valuable target for bioconjugation and drug delivery.
The functional groups in Methylamino-PEG5-azide work together to enable targeted drug delivery, reduce toxicity and immunogenicity, and improve the pharmacokinetics of drugs. Its unique chemical properties make it a valuable tool in drug discovery and development, with promising applications in various areas of medicine.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.